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How Age Affects Fertility and ICSI/IVF Success Rates: What You Need to Know Before Starting ICSI/IVF in Thailand

How Age Affects Fertility and ICSI/IVF Success Rates: What You Need to Know Before Starting ICSI/IVF in Thailand

When it comes to fertility, age is one of the most important factors, especially for women. As age increases, the quality and quantity of eggs decline, making difficult to conceive naturally. However, with advancements in assisted reproductive technology such as IVF (In Vitro Fertilization) and ICSI (Intracytoplasmic Sperm Injection), women still have the opportunity to build a family,even at a later age.

For those considering ICSI/IVF in Thailand, understanding how age impacts fertility and success rates of ICSI/IVF can help you make informed, timely decisions. SAFE Fertility Clinic, a leading fertility clinic with RTAC certification, offers comprehensive fertility solutions and personalized care for local and international patients alike.

Why Age Matters in Fertility?

The optimal age for pregnancy is typically between 20 and 35. During this period, the female body is generally at its reproductive peak in terms of both egg quality and overall health. After 35, egg quantity significantly decreases whilst the risk of chromosomal abnormalities increases,affecting both natural conception and assisted reproduction.

  • Key age-related fertility factors include
    • Decrease in egg reserve by age
      • At birth: approximately 1–2 million eggs.
      • At first menstruation: around 300,000–400,000 eggs remain.
      • Eggs gradually decline with each cycle and are depleted by menopause (~age 50).
      • If you plan to conceive later, consider fertility testing and egg freezing in advance to preserve egg quality.
    • Increased chromosomal abnormalities
      • As age increases, so does the likelihood of chromosomal issues in eggs.
      • This can lead to miscarriage or genetic conditions like Down Syndrome.
      • Women over 35 have a higher risk of chromosomal abnormalities in embryos.

The Right Age for Pregnancy Helps Prevent “Complications During Pregnancy”

Older age is associated with higher risks of:

  • Preeclampsia
  • Gestational Diabetes
  • Preterm Birth

Furthermore, women over 35 have a higher miscarriage rate and may experience implantation failure due to egg quality.

ICSI/IVF at a reputable clinic in Thailand can provide early screening and tailored treatment to reduce these risks.

How to Increase ICSI/IVF Success by Age Group

Age under 35

ICSI/IVF Success Rate: 70–80% per cycle*

Recommendations:

  • Maintain a balanced diet and exercise regularly
  • Get a pre-conception fertility check-up early
  • If not ready for pregnancy, consider egg freezing
  • Getting pregnant at an optimal age helps improve ICSI/IVF success

Age 35–39

Success Rate: ~70% per cycle*

Recommendations:

  • Test overall health and hormone levels.
  • Consider PGTseq-A (genetic screening) to select healthy embryos.
  • ICSI/IVF at this stage can still result in a healthy pregnancy with proper care.

Age 40 and above

Success Rate: 65–70% per cycle*

Recommendations:

  • Consult a fertility specialist for thorough embryo screening.
  • Focus on overall health to reduce complications.

*Based on SAFE Fertility Clinic’s clinical pregnancy rate from frozen embryo transfers (FET) using PGT-A screening between 2021–2024.

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Lifestyle Tips to Boost Your ICSI/IVF Success

In addition to medical treatment, your daily lifestyle plays a critical role in reproductive health. Whether you're planning ICSI/IVF in Bangkok or traveling for fertility care in Thailand, these proactive measures can support your journey:

Nutrition

  • Consume fertility-friendly foods rich in folic acid, omega-3s, zinc, and CoQ10.
  • Avoid trans fats, processed foods, and foods high in sugars.

Exercise

  • Engage in moderate activities like walking or yoga 3–5 times per week.
  • Avoid intense workouts that could disrupt hormonal balance.

Stress Reduction

  • Practice meditation or deep breathing to lower cortisol levels.

Sleep

  • Aim for 7–8 hours of sleep per night, ideally before 10 PM.

Avoid Toxins

  • Limit exposure to BPA, pesticides, and heavy metals from seafood.
  • Avoid smoking, alcohol, and excessive caffeine.

Conclusion: ICSI/IVF in Thailand Offers New Hope for All Ages

Age is a major factor in fertility, but with proactive health management and access to modern fertility technologies such as ICSI/IVF in Thailand, women can still achieve pregnancy safely and successfully.

At SAFE Fertility Clinic, we offer personalized fertility solutions, advanced genetic testing (like PGTseq), and compassionate care for every patient,regardless of age. Whether you’re just starting to plan or ready to embark on your journey to parenthood, our expert team is here to support you at every step.

Article by: Kamolrat Mee-o-partmongkon, M.D. (Dr.Bo)

SAFE Fertility Group PCL, Gaysorn Amarin and Ramintra Branch Medical License Number 41300

Reference

  • การตั้งครรภ์ในสตรีอายุมาก (Pregnancy in advanced maternal age). ภาควิชาสูติศาสตร์และนรีเวชวิทยา คณะแพทยศาสตร์ มหาวิทยาลัยเชียงใหม่. https://w1.med.cmu.ac.th/obgyn/lecturestopics/topic-review/5792/
  • อายุของแม่...กับการตั้งครรภ์. คณะแพทยศาสตร์ศิริราชพยาบาล มหาวิทยาลัยมหิดล. https://www.si.mahidol.ac.th/th/healthdetail.asp?aid=509
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