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15.09.25

Fresh vs Frozen Embryo Transfer: What’s the Difference? Which One Is Right for You?

Fresh vs Frozen Embryo Transfer: What’s the Difference? Which One Is Right for You?

Embryo transfer is one of the most important steps in the IVF/ICSI journey—bringing embryos back into the uterus for pregnancy. There are two main approaches:

Fresh Embryo Transfer

The embryo is transferred within the same cycle as egg retrieval and fertilization, typically on Day 2–5 of culture.

  • Best suited for: Women in good health, with balanced hormones, a receptive uterus, or those who prefer immediate transfer without waiting.
  • Pros: Immediate transfer in the same cycle, shorter overall treatment time, and no freezing costs.
  • Considerations: High estrogen levels after stimulation may affect the uterine lining and increase risk of OHSS (Ovarian Hyperstimulation Syndrome). Transfer timing also depends on embryo development.

Frozen Embryo Transfer (FET)

Embryos are cryopreserved using vitrification and transferred in the next cycle or when the body is ready.

  • Best suited for: Women with high hormone levels, risk of OHSS, or those whose uterus is not yet ready for implantation. Also ideal for those who want more flexibility in planning.
  • Pros: More time to balance hormones and prepare the uterus, option to perform PGTseq-A (chromosome screening) for embryo selection, flexibility in timing, and ability to store embryos for future use.
  • Considerations: Higher cost and longer process, since transfer happens in a later cycle.

Today, FET is becoming increasingly popular as it allows better control over timing and conditions, and is often associated with higher success rates.

Fresh Embryo Transfer or Frozen Embryo Transfer, which option is right for you?

Both fresh and frozen embryo transfers have their own benefits and limitations. The best choice depends on your health, hormone levels, embryo quality, and lifestyle convenience—and should always be guided by your fertility specialist.

At SAFE Fertility Clinic, our specialists, advanced lab technology, and international standards are here to help you plan the safest and most suitable embryo transfer for your journey.

Article by: Peangpailin Voradithi, M.D. (Dr.Tangmo)

SAFE Fertility Group PCL, Gaysorn Amarin Branch

Medical License Number 46855

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