Intracytoplasmic sperm injection (ICSI) is an increasing the chances of fertilization in infertility

ICSI is a method to solve infertility and can increase the fertilization rate. In ICSI, select the most potent of sperm, and the single sperm is directly injected into an egg for fertilization. Once the embryo is mature enough, it will be transferred back into the uterine cavity and allows continuing development in the uterus. At present, ICSI is a highly effective medical technology for infertility. In this article, The SAFE Fertility Group describes the ICSI procedures, including the advantages and disadvantages of ICSI, according to the article below.

Get to know about ICSI

Get to know about ICSI Intracytoplasmic sperm injection (ICSI) is an in-vitro fertilization method with the selection of high-quality egg and sperm from the couples. After injection of the strongest sperm into the selected egg and follow by fertilization step. The process are controlled by the advanced technology and our scientists. The embryo will continue to grow and reach a blastocyst stage, where it will then be transferred back to the uterus to continue growing during pregnancy and fetal development inside the uterus.

According to statistics collected by SAFE Fertility Group. The success rate of ICSI is over 70%, which makes it a highly effective method of in vitro fertilization. It is recommended for couples with infertility or preventing a genetic diseases. When you need to test chromosomes PGT-A by NGS gives cost-effective results. A specialist and personal assistants will take care of you. We are ready to stand by you until you achieve your purpose, along with our experience of over 16 years.

Who needs ICSI?

Intracytoplasmic Sperm Injection (ICSI), it is a method of conception using the concept of medical sciences that can help to increase the chances of pregnancy for couples who cannot conceive naturally. Additionally, ICSI is suitable for people with the following issues:

• Couples have infertility, female infertility such as irregular menstruation or male infertility such as poor sperm quality.
• Couples have not had success with the intrauterine insemination (IUI) treatment.
• Couples plan to have children in the future.
• Women have many problems with the uterus or ovaries such as endometriosis and a blocked fallopian tube.
• Women have ovulation disorder and primary ovarian insufficiency.
• Men who have undergone a vasectomy and want to have children.

The ICSI Process

The ICSI procedure for infertility, before starting the process, both male and female must be done physical examination to ensure sperm and egg quality, also pregnancy readiness. If all preparations are complete, the ICSI procedure will commence with the following steps:

Ovulation Stimulation

Ovulation stimulation is an injection to stimulate the eggs to grow to an appropriate size. The process starts on days 2-3 of the menstrual cycle. The doctor will check the readiness of the uterus and blood hormone levels. Then, hormones will be injected to stimulate the egg cells for 8-10 days until the eggs reach the appropriate size. However, eggs stimulation may cause side effects such as nausea, vomiting, or stomachache.

The doctor will follow up with ultrasounds and monitor the results. When the eggs reach an appropriate size and ready for retrieval, the doctor will administer an injection to trigger ovulation and collection the eggs during the next ICSI process.

Egg Retrieval

Once the eggs have reached the appropriate size for ICSI treatment, the doctor will stimulate ovulation and next retrieve the eggs within 36 hours. After that the patient was treated with mild sedation before egg retrieval through the vagina. The egg retrieval takes about 15-20 minutes surgical procedure. The doctor will collect the sperm and egg on the same day.

ICSI fertilization

Once completed getting the eggs and sperm. The doctor's team will inject only one healthy sperm directly into the egg for fertilization and then, the process will enter embryo culture.

Embryo Culture in the Laboratory

The embryo culture process for ICSI takes 3-5 days in a laboratory within a controlled environment is closed to inside of the human body and controlled by modern technology. The mature embryo was monitored by scientists and transferred into the woman's uterus in the next process.

The embryo transfer process

Embryo transfer into the uterus can be categorized into two types: fresh embryo and frozen embryo transfer. Fresh embryo transfer is a procedure where the embryo is transferred to the uterus immediately after 3-5 days of fertilization,and Frozen embryo transfer is a procedure where the embryo is transferred into the uterus whenever you are ready to conceive and the embryo can be frozen for 5-10 years.

However, some of the side effects after an embryo transfer such as a bloated stomach and abdominal cramps. Doctors will schedule a follow-up appointment 1-2 weeks later to check after embryo transfer.

Advantages of ICSI

ICSI is an alternative pregnancy option and it is suitable for couples who have infertility because there is a high chance of a successful pregnancy. The advantages of ICSI are as the follows:

• You can choose the timing of pregnancy.
• If you want to test the genetic screening in embryo, you can test chromosomes by PGT-A with NGS to avoid genetic abnormalities and genetic diseases such as Down syndrome, Thalassemia, etc.
• ICSI can increase the chance of having children and getting more embryos. An embryo has a higher chance of successful pregnancy because the injected sperm directly into an egg and makes the chance of fertilization higher than natural fertilization.

Disadvantages of ICSI

Since ICSI treatment, the egg and sperm are fertilized outside the body. This method is not natural fertilization, it requires a lot of expertise in the field to have a healthy pregnancy outcome. Additionally, the various stimulating injections may cause side effects and some complication.

ICSI treatment must be conducted and overseen by a team of specialists in reproductive medicine within a healthcare facility that holds appropriate accreditation. Increasing the chance of pregnancy and reducing the risk of other complications.

Factors affecting ICSI Pregnancy Outcome

There are numerous factors associated with ICSI that can influence pregnancy outcomes, including the quality of eggs and sperm, which have low quality and are not healthy and physical health issues for women. The chance of successful fertilization and pregnancy is reduced. Endometrial atrophy and endometrial hyperplasia have an effect on reducing the chance of successful pregnancy.

Furthermore, the expertise and competencies of teams comprising specialized physicians are equally significant.Without the specialist expertise, there are lower chances of pregnancy and riskier outcomes.

The success rate of ICSI

ICSI success rate, with pregnancy rates approximately 40-50%. Genetic screening of embryos and selecting the highest quality embryo before transferring back into the uterine cavity. It helps to increase pregnancy rates to 70-80%. However, the collection process of eggs and sperm, and embryo fertilization for pregnancy need a high expert team of doctors, so the couples need to choose a clinic offering trusted ICSI treatment and have the highest chance of a successful pregnancy.

Select ICSI treatment at SAFE, a prominent authority in the field of infertility care.

Select SAFE Fertility Group, a prominent authority in the field of infertility care and reproductive medicine with over 18 years of experience. In order to ensure a successful pregnancy, we provide consultations, treatment plans, and attention to every detail.

We use only international standards of technology and equipment. At SAFE Fertility Group, we have a doctor team, scientists, and personal assistants who are ready to assist you in completing your family through pregnancy. Feel free to contact us if you have any questions. https://www.safefertilitygroup.com/th/contact-safe